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RBCs contain HbS and with oxygen are flexible discs. When O2 is low, RBCs sickle or become elongated and rigid. As that blood circulates the body may have decreased oxygen levels. The RBCs (or erythrocytes) are unable to pass easily through small arteries so the cell membrane is damaged and tissue damage and multiple infarctions occur.

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12y ago
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Q: Explain why vascular occlusions are common in patient with sickle cell anemia?
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