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Excedrin (as well as Excedrin Migraine which contains the same ingredients), contains Acetaminophen (Tylenol), Aspirin, and Caffeine.
Acetaminophen works to relieve pain and has a half-life of 2-4 hours. So, anywhere from 4-8 hours the acetaminophen will be completely gone from your body.
Aspirin works by blocking pain signals before they get to the brain, also by reducing inflammation (where much of migraine pain is an inflammatory response - this is especially important). Its half-life (for the normal dosage of Excedrin) would be about 3.1-3.2 hours. So, at about 6 hours all aspirin would be gone from your body.
Caffeine works both by increasing the rate of absorption of the medication and by working as a vasocontrictor on blood vessels that are dilated due to inflammation. Taking two Excedrin is about the same as drinking a cup of coffee. The half-life of caffeine is about 5 hours.
The directions for Excedrin say to take 2 tablets every 6 hours. This is both because they don't want you overdosing on the medication and because at about 6 hours the pain relieving effects will be wearing off from all three components.
If you are taking over-the-counter medications for your headaches and are finding they are doing little to nothing for your pain, see your doctor. And please read the labels of any other medications your are taking to make sure they do not contain an NSAID (like ibuprofen - which is Motrin, Advil) or Acetaminophen (which is in every form of Tylenol and in some cold medications as well).
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Does Excedrin work for back pain?
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What is the purpose of Excedrin?
Excedrin is a general pain relief medicine. It can be used for head aches--both migraine and tension, muscle aches and sores, tooth pain and even menstrual cramps.
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