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Hexokinase is regulated by feedback inhibition of Glucose-6-Phosphate. Otherwise, you would make more glucose-6-phosphate than the cell can use at one time. you could also reduce phosphate concentrations needed for making ATP, and set up an osmotic gradient which could lead to swelling of the cells
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Which has a higher affinity for glucose: hexokinase or glucokinase?
Hexokinase
What is hexokinase?
Hexokinase is an enzyme that catalyzes the first step in glucose metabolism by phosphorylating glucose to form glucose-6-phosphate. This enzyme plays a crucial role in maintaining glucose homeostasis and energy production in cells. There are different isoforms of hexokinase that are found in various tissues, each with specific functions and regulatory properties.
Which has a higher Vmax: glucokinase or hexokinase?
Glucokinase
What is a function of enzyme protein for example hexokinase?
Hexokinase is an enzyme involved in the phosphorylation of hexose (five carbon sugar). It speeds the process on adding a phosphorus to the sugar.
Which of these enzymes catalyzes the first reaction in glycolysis?
Hexokinase
The enzyme hexokinase binds to glucose and ATP during the chemical reaction. at what location do they connect?
Hexokinase binds to glucose and ATP at its active site, which is a specific region on the enzyme that facilitates the chemical reaction. The binding of glucose and ATP induces a conformational change in hexokinase, allowing for the efficient transfer of a phosphate group from ATP to glucose, forming glucose-6-phosphate. This process occurs in the cytoplasm of the cell, where hexokinase is primarily located.
How does ATP inhibit hexokinase?
ATP inhibits hexokinase by competing with glucose for binding at the active site of the enzyme. When ATP is bound, it causes a conformational change that prevents glucose from binding and being phosphorylated. This inhibition helps regulate the glycolytic pathway by ensuring that hexokinase is only active when ATP levels are low.
Which of the following is characteristic of hexokinase (as opposed to glucokinase)?
It is not inducible by insulin
Which of the following enzymes catalyzes an unfavorable step in glycolysis?
Hexokinase
What substrate is converted into glucose 6 phosphate by the enzyme hexokinase?
Glucose is the substrate that is converted into glucose 6-phosphate by the enzyme hexokinase. Hexokinase catalyzes the phosphorylation of glucose to glucose 6-phosphate in the first step of glycolysis.
Glucose to glucose 6-phosphate. Irreversible. Hexokinase/gluckokinase. Requires ATP and Mg2?
The conversion of glucose to glucose 6-phosphate catalyzed by hexokinase/glucokinase is an irreversible reaction that traps glucose within the cell. This process consumes one molecule of ATP and requires Mg2+ as a cofactor. Hexokinase has a high affinity for glucose and is present in most tissues, while glucokinase is found primarily in the liver and pancreas with a lower affinity for glucose.
Which enzyme in glycolysis is responsible for the conversion of glucose to glucose 6-phosphate?
Hexokinase
