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What are the three inhibitors of tca cycle?
1.) Increases in NADH, Succinyl CoA, ATP, Citrate inhibit citrate synthase. 2.) Increases in ATP will inhibitisocitrate dehydrogenase. 3.) Increases in succinyl CoA and NADH will inhibit succinate thiokinase.
What reaction does the enzyme hexokinase catalyze?
First step of glycolysis- the phosphorylation of glucose to glucose-6-phosphate.
An enzyme citrate synthase in the Krebs cycle is inhibited by ATP What type of inhibition would this be?
Citrate synthase is inhibited by ATP. Obviously, the Krebs cycle produces ATP. This is the first step and one of the major regulatory steps in the pathway. If the cell has plenty of ATP, then it wouldn't need to keep making it, thus the pathway needs to be shut off. ATP inhibits the enzyme to shut off the pathway. This is an example of feedback inhibition (you can also call it negative inhibition or even product inhibition). Feedback inhibition is when the products of a certain biochemical pathway inhibit earlier enzymes, shutting down the pathway.
What hormones regulate glycolysis?
The hormones that regulate glycolysis are insulin and glucagon.Insulin is released by the pancreas when blood glucose levels are high for example after eating. Glucogen is released by the pancreas when blood glucose levels drop too far. It has the opposite effect of insulin.
What process would stop if a poison blocked ATP synthesis?
There are so many things that could possibly happen if a poison blocked ATP synthesis. This will hinder all cell activities which obtain energy from ATP molecule and this could lead to loss of life as organisms depend on cell activities to survive.
Glucose to glucose 6-phosphate. Irreversible. Hexokinase/gluckokinase. Requires ATP and Mg2?
Glucose to glucose 6-phosphate. Irreversible. Hexokinase/gluckokinase. Requires ATP and Mg2+
How does cyanide inhibit mitochondrial function?
ATP decreases
Why ATP is needed not GTP for hexokinase reaction?
Atp is universal energy currency used in most reactions while GTP is used only in protein synthesis .
Name one reaction were ATP is required?
The first reaction of glycolysis, where glucose is phosphorylated (a phosphate group is added) to give glucose - 6 - phosphate requires ATP. This reaction is catalyzed by the enzyme hexokinase
What is hexokinase?
a hexokinase is an enzyme that catalyzes the phosphorylation of hexoses.
Which has a higher affinity for glucose: hexokinase or glucokinase?
Hexokinase
Which of the following is true of phosphofructokinase (PFK)?
High levels of ATP inhibit PFK
What are the three inhibitors of tca cycle?
1.) Increases in NADH, Succinyl CoA, ATP, Citrate inhibit citrate synthase. 2.) Increases in ATP will inhibitisocitrate dehydrogenase. 3.) Increases in succinyl CoA and NADH will inhibit succinate thiokinase.
Why Hexokinase phosphorylated the glucose at first step of glycolysis?
The first step in glycolysis is catalyzed by hexokinase, an enzyme with broad specificity that catalyzes the phosphorylation of six-carbon sugars. Hexokinase phosphorylates glucose using ATP as the source of the phosphate, producing glucose-6-phosphate, a more reactive form of glucose.
Which metabolic poison can inhibit the production of ATP and therefore stop active transport?
Potassium cyanide
What proteins require ATP to function?
Proteins that carry out active transport such as Na/K ion channels requires ATP. Also metabolic enzymes such as kinases which can phosphorylate its substrate also need ATP; For example hexokinase convert the glucose to glucose 6 phosphate in the first glycolysis step with the expense of an ATP molecule.The muscle protein myosin can use ATP to flex its head, pulling on the muscle protein actin, causing the actin filament to slide past the myosin filament producing contraction of the muscle. Sometimes myosin does this with just ion transfers without requiring ATP, but the reaction using ATP is more dependable.
How is hexokinase regulated and why is it regulated?
Hexokinase is regulated by feedback inhibition of Glucose-6-Phosphate. Otherwise, you would make more glucose-6-phosphate than the cell can use at one time. you could also reduce phosphate concentrations needed for making ATP, and set up an osmotic gradient which could lead to swelling of the cells
