With a milder form of the condition, individuals tend to be shorter than expected for their age, develop corneal clouding, and live longer
Individuals with a more severe form of MPS VI can develop airway obstruction, hydrocephalus (extra fluid accumulating in the brain), and abnormal growth and formation of the bones
Common problems include abnormal heart valves, narrowing of the blood vessels in the heart, and weak heart muscles (cardiomyopathy). Patients with MPS I H and the severe form of MPS II usually have damage to the mitral valve
Scheie syndrome is considered the mild form of MPS I. Individuals with Scheie syndrome usually have normal intelligence
MPS I, MPS III, MPS IV, MPS VI, MPS VII, and MPS IX are inherited in an autosomal recessive manner which means that affected individuals have two altered or non-functioning genes,
Seizures are a problem found in severe forms of MPS and especially in MPS III (Sanfilippo syndrome). Patients with seizures are given a type of prescription medication known as an anticonvulsant.
MPS IV B is considered the milder form of the condition. The enzyme, beta-galactosidase, is deficient in MPS IV B. The gene involved with MPS IV B (GLB1) is located on chromosome 3.
MPS III is a variable condition with symptoms beginning to appear between ages two and six years of age. The condition is characterized by developmental delay, behavioral problems, and mild physical problems
Individuals with Hurler syndrome tend to have the most severe form of MPS I. Hurler syndrome may also be referred to as severe MPS I.
Mutations in the iduronate-2-sulphatase (IDS) gene cause both forms of MPS II (mild and severe). Nearly all individuals with Hunter syndrome are male, because the gene that causes the condition is located on the X chromosome.
Hurler (MPS I H), Hurler-Scheie (MPS I H/S), Scheie (MPS I S), Hunter (MPS II), Sanfilippo (MPS III), Morquio (MPS IV), Maroteaux-Lamy (MPS VI),
National MPS Society provides support for families with Morquio Syndrome patients. They have a website.
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