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How can mutation in single DNA base affect the production of normal proteins?
Wiki User
∙ 12y ago
mutation in a single DNA base may have no effect on the phenotype or may have a great effect. the best example on this is sickle cell anaemia.
haemoglobin is formed of 2 alpha chains of protein and 2 beta chains, this is the beginning of the a.a sequence of beta chains: val-his-leu-thr-pro-glu-glu-lys
in some people, the mutation causes the substitution of a single thymine base with adenine. this causes one of the glutamine molecules with valine so the chain is this:
val-his-leu-thr-pro-val-glu-lys .
this very slight change causes the blood to form fibrous structures when it's not combined with oxygen. this causes many rbcs to be useless at transporting oxygen and the fibers may get stuck in capillaries which will prevent unaffected cells from getting through.
Wiki User
∙ 12y ago
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Will cells with mutations always make normal proteins?
No. Cells that have experienced mutation will most likely not have normal cells their cells will be all messed up.
What is normal mutation?
a normal mutation when something is evolving into something bigger or stronger
How can mutation in DNA disrupt proper functioning?
A mutation in a gene can change the amino acid sequence of the protein the gene makes. These alterations in the proteins' primary structure may affect the secondary, tertiary, and quaternary structure, all which have to be exact for proper functioning. The mutation in a gene can also put a STOP message in the sequence so the protein is terminated prematurely, leading to a truncated polypeptide. Some polypeptides simply won't work, and when critical proteins are not functioning, the cell can cease to run metabolic reactions or undergo mitosis. Other polypeptides will become deleterious and directly harm the cell.
What does the mutation rule state?
The mutation rule states that the state of mutations are in a mutated state when compared to a normal state. This is a slight mutation from the original stated rule.
A mutation in mice causes the coat to be twice as large as normal in what enviorments would this mutation be helpful?
it would be in the industrial invirments
When when a mutation results in no significant change in the production of a of a functional protein?
When a mutation does not change the result of a normal production of a protein is called harmless. This is because it does no harm to the individual.
Will cells with mutations always make normal proteins?
No. Cells that have experienced mutation will most likely not have normal cells their cells will be all messed up.
What will mutation do if it does not occur in sex cells?
Mutations which do not occur in sex cells are not passed on to the next generation. The mutation will only affect the individual. They could therefore have normal offspring.
What is normal mutation?
a normal mutation when something is evolving into something bigger or stronger
A new mutation in mice cause the coast to be twice as normal In what environment would this mutation be helpful why?
New mutation in mice causes the coast to be normal in today's world. This is a well ask question.
How might normal variations in your genes affect your response to different medicines?
Small, but normal, variations in your genes can produce proteins that work differently from those of your friends or relatives. This can affect how you respond or don't respond to different medicines
Should you have Cancer?
No, Cancer is a mutation. It is not normal.
How can mutation in DNA disrupt proper functioning?
A mutation in a gene can change the amino acid sequence of the protein the gene makes. These alterations in the proteins' primary structure may affect the secondary, tertiary, and quaternary structure, all which have to be exact for proper functioning. The mutation in a gene can also put a STOP message in the sequence so the protein is terminated prematurely, leading to a truncated polypeptide. Some polypeptides simply won't work, and when critical proteins are not functioning, the cell can cease to run metabolic reactions or undergo mitosis. Other polypeptides will become deleterious and directly harm the cell.
The condition of normal tear production is?
Normal tear production.
What does the mutation rule state?
The mutation rule states that the state of mutations are in a mutated state when compared to a normal state. This is a slight mutation from the original stated rule.
What does mutation rule states?
The mutation rule states that the state of mutations are in a mutated state when compared to a normal state. This is a slight mutation from the original stated rule.
How does bacterial diseases affect the body?
through the production of toxin, by an allergic reaction of the body to the bacteria and/or by destruction of normal tissues.
