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The Mandan tribe first encountered Europeans in 1738 and they were said to have been very friendly and welcoming. Over the next 100 years there is no account of Mandans behaving in any hostile way towards trappers, traders, settlers and others they met; they were recorded by Lewis and Clark as friendly people.

Constant warfare with other tribes, particularly the various Sioux tribes, the Cheyenne and Arapahos, kept the Mandan population small, but a severe epidemic of smallpox in 1837 reduced them to just 125 people - not enough to keep the tribe from eventual extinction. It was for that reason that they joined together with the Arikaras and Hidatsas, intermarrying with both.

With troubles like these the Mandans were in no position to pose any kind of threat to white settlers.

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Q: How did mandan Indians act toward white settlers?
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