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Cheir: Suture the lacerations and Cheir will attack. Hold the laser on Cheir to defeat it. After two waves, two more Cheir will fuse together. These fused Cheir do a asterisk (*)shaped cut which plummets the patient's vitals. Hold the laser on the fused Cheir as well. And then you're done. Do know that Mutant Cheir can attack with tumors and gashes as well. If you run low on laser, fix the wounds first, then continue to damage Cheir.

Soma: Soma is a big blue blob. It will sometimes leave red tumors on the organ which will damage vitals, so laser the tumors away. Hold the drain on Soma in order to expose the core. Once the core is exposed, Soma will disperse blue stray tissue on the operating field, which are supposed to be drained away since they suck away vitals. If the blue Soma tissue hardens, laser it and cut it out, then remove it. If the red tumors harden, treat them like a normal tumor. After a while, Soma will split up, and if you leave the false core alone, it will disperse extra blue Soma tissue. So just burn the core, rinse and repeat.

Ops: A minor note here: You can't kill the ends to stop the nutrients so don't even try. The ends will shoot [blue] nutrients at the Ops core and if they reach the core, you'll take massive damage. To get rid of the nutrients, just drain them. And laser the core when you have time. Also, if there are tumors on the operating field, then if nutrients reach the core, it will burst and cause even more damage. After a while it will start discharging something larger and you have LASER the red stuff. (This surgery just has to have been designed for co-op where you have one guy destroying the nutrients, and the other guy lasering the core. Thank you, RaikouRider for pointing that out.) It will also split up eventually. In that case, just laser both of them and enjoy the sound of DEFEAT!

Onyx: Find Onyx with the ultrasound and make an incision. Then inject it with the Onyx Serum. If you wait too long though, it will emerge and... oh, no... it will do Savato's famous star laceration set... After a while, Onyx will start making copies. This part has stumped many people by implying, "Well, which is the real Onyx!?" and they always manage to pull out a fake. Remember that the real Onyx has FOUR blue spots on his head and the copies only have THREE. If it's the mutated strain it will cause blood vessels to appear eventually and you'll take damage faster. And you won't need the ultrasound for this part by the way. (Unless you can't see the whole organ at once.) Anyway, inject Onyx with the serum a couple more times and it's Game Over for Onyx. Try never to let Onyx attack at all, since it deals massive damage, especially in the X Missions where 1 single attack deals a massive 75 vital damage.

Brachion: Brachion will start with three long arms extending from the core. Toxins will move toward the ends of the arms and if they reach the grapplers... Um... you don't wanna know. Okay, fine, I'll tell you. All of the grapplers regenerate if the toxins make to the ends, and the patient takes vital damage. To prevent this, pinch the arms to reset the toxins. You may pinch the segment of the arm where the toxins are at to get rid of the toxins and crush the arm, making it double trouble for Brachion. Anyway, to defeat Brachion, you inject the Brachion Serum into each of the grapplers to stop their movement. Then cut it off with the scalpel and extract them. After a while, it will start spawning four arms. Once you extract the grapplers four or five times, Brachion will die.

Cardia: Okay, I'll only be saying this once so I'll emphasize it for you: DO NOT USE YOUR HEALING TOUCH WHATSOEVER UNTIL I SAY SO!!!! YOU HAVE BEEN WARNED! Okay. Phase 1: Gel the membrane and scalpel it. Now extract to the tray. You can extract multiple parts at once, but if you want more points/chain remove each membrane seperately. And another major note: Don't let Cardia reach a red part of the membrane whatsoever because if it does, your maximum vitals will decrease for the rest of the operation. Anyway, after extracting 3-4 membranes... Okay! First phase over! Now come's the hard part. That's right. Cardia goes berserk and the music gets so much more awesome! Cardia will now either form lacerations or tumors in a chain. If it's tumors, then Cardia will release a ripple that if it touches the tumors, it will cause massive damage when the tumors rupture. Anyway, just laser the core after extracting the tumors while Cardia is rippling. (And, yes, this is getting old.) After Cardia takes 5-6 hits... Oh noes!!!

This attack has become what I like to call the Ring of Death. She'll spawn like, twenty tumors in a circular pattern. Remember when I told you not to use your Healing Touch? Now's the time. If you're playing as Markus, extract the tumors. If you're playing as Valerie, leave the tumors alone and concentrate on burning the core one last time. And... you defeated all six Stigma! Victory dance! Woohoo!

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Q: How do you beat Stigma in Trauma Center New Blood?
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