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Half-life is trationally employed for the assessment of the degree of accumulation (R) of drug in the body as follows:

R=1/(1-exp(-K*tau)....(1)

This equation applies for single-compartment model drugs. However, for drugs observing multiple compartmental bevavior, the terminal half-life, t0.5(beta), is used. This will, invariable, results in over or under estimation of the drugs' accumulation ration.

As a matter of fact an effective elimination rate constant should, per necessity, take into consideration the exact distributional characteristics of the drug in question. i.e the rate of drug trasfer from one compartment to the other and vis-a-versa.

The following relationship could be of use in this regard:

ERC = (apha*beta)/(K12+k21), where ERC stands for Effective Elimination Rate Constand...

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Q: How do you calculate a drugs half life?
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