PCT may be acquired, typically as a result of disease (especially hepatitis C), drug or alcohol use, or exposure to certain poisons. May also be inherited as an autosomal dominant disorder, remains latent in most.
Acute porphyrias produce severe attacks of pain and neurological effects.
AIP is inherited as an autosomal dominant trait.
Swedish porphyria, pyrroloporphyria, and intermittent acute porphyria.
Yes, in acute intermittent porphyria, both pyrroles and porphyrins are excreted in the urine to an excessive degree.
ALA dehydratase deficiency porphyria (step 2); acute intermittent porphyria (step 3); hereditary coproporphyria (step 6); variegate porphyria (step 7).
Hormones (oral contraceptives, menstruation, pregnancy), drugs and dietary factors.
Hepatoerythopoietic porphyria (HEP) affects heme biosynthesis in both the liver and the bone marrow and appears due to inheriting an autosomal recessive gene.
Lennart Wetterbert has written: 'A neuropsychiatric and genetical investigation of acute intermittent porphyria' -- subject(s): Heredity of disease, Mental illness, Prophyria
Non-acute porphyrias present as chronic diseases.
Approximately five to 10 per 100,000 people in the United States carry a gene for AIP, but only 10% of these people ever develop symptoms of the disease.
Most people who inherit the gene for acute porphyria never actually develop symptoms. However, some people will have nausea, muscle fatigue, and purple urine.
Usually do not occur unless triggered by a substance. Attacks feature abdominal pain, nausea, vomiting, constipation, muscle weakness/pain, deep red urine, hallucinations, seizures, mood changes.
CEP is inherited in an autosomal recessive manner. Onset of dramatic symptoms usually occurs in infancy, but may hold off until adulthood.
Congenital erythropoietic porphyria (step 4); porphyria cutanea tarda (step 5); hepatoerythopoietic porphyria (step 5); erythropoietic protoporphyria (step 8).