Take the SEPTA train.
Take the Uptown E train (of the A-C-E, the blue line) from 34th Street-Penn Station to 53rd Street-5th Avenue. Fifth Avenue is one block west of Madison Avenue.
30th Street Station
Take the subway eastbound from the Amtrak station (30th Street Station) to 11th Street.
Take the Uptown 6 train from 33rd Street (at Park Avenue South, 1 block east of Madison) to 51st Street.The 51st Street station on the 6 train is connected to the Lexington Avenue-53rd Street station on the E and M trains, so you can transfer without exiting the subway system.Transfer to the 53rd-Lexington station, and take the Downtown E train 2 stops to 7th Avenue (at 53rd Street) or to the next stop, 50th Street (at 8th Avenue). The walk is about equidistant from each station: 3 street blocks or 1 avenue block.
East. Penn Station is between 8th and 7th Avenues. Park Avenue is 5 blocks east of 7th Avenue.
Tiffany and Co. is located at 727 Fifth Avenue, at the southeast corner of 57th Street. Take the Uptown E train (of the A-C-E, the blue line) from 34th Street-Penn Station to 5th Avenue-53rd Street. Then walk 4 blocks up Fifth Avenue to 57th Street.
Take the Downtown 1 train (of the 1-2-3, the red line), 1 stop, from 34th Street-Penn Station to 28th Street (at 7th Avenue).
The American Girl store is at the corner of 5th Avenue and 49th Street. Take the Uptown E train (of the A-C-E, the blue line) from 34th Street-Penn Station to 5th Avenue-53rd Street. Then walk 4 blocks down 5th Avenue to 49th Street.
Take the Uptown 6 train (of the 4-5-6, the dark green line) from 23rd Street (at Park Avenue South, which is Park Avenue below 34th Street) to 42nd Street-Grand Central Station. At Grand Central Station, get the Manhattan-bound 7 train (the purple line), one stop, to 42nd Street-5th Avenue.This station is connected to the 42nd Street-Bryant Park Station (at 42nd Street and 6th Avenue) on the B-D-F-M, the orange line. So you can either exit at 42nd Street and 5th Avenue, and walk one block west above ground, or walk through the tunnel that connects the two stations, and exit at 42nd and 6th.
Walk two blocks to 13th & Market Streets. Take the subway from 13th Street to 30th Street Station.
Since the eastern entrance to Penn Station is located on 7th Avenue, the distance is zero. However, the answer is deceiving because Penn Station is massive. It spans between 7th Avenue and 8th Avenue (the equivalent of 4 city streets), from east to west, and between 31st Street and 33rd Street from south to north. So, yes, it is true that the entrance to Penn Station is situated directly on 7th Ave. But, once inside, one might find himself walking several city blocks to get to the actual departure platform for his train or vice versa, from his train to 7th Ave.
They are about a mile apart. Grand Central Station is on East 42nd Street and Lexington Avenue, and the heart of Times Square is West 42nd Street and 7th Avenue. They are 5 avenue blocks apart. Normally, 3 to 4 avenue blocks equals a mile, but at 42nd Street, the distance between one of the blocks (Park Avenue to Lexington Avenue) is abnormally short.