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The time release for products like MSContin (morphine sulfate) and Oxycontin (oxycodone hcl) is not in the coloured coating, it is in the entire matrix of the pill. Crushing the pill before oral ingestion defeats the time release which is why controlled release products generally state that one should not do this.

Other time release technology is used in products like Kapanol (morphine sulfate), in the form of tiny beads designed to slow release the drug. They are contained in a gel cap which melts after oral ingestion, releasing them to break down slowly. In the same way, if the beads are emptied out of the gel cap and finely powdered before oral ingestion, the time release is defeated, and a potentially dangerous amount of drug will be released at one time.

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Q: How do you take time release coating off morphine?
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