http://en.wikipedia.org/wiki/Enzymes
this web address explains everything
It is true that the shape of an enzyme is what allows it to do it's job.
What an enzyme does is based on its shape, therefore you would have to change it on a molecular level in order to alter its job.
The enzyme ptyalin ,or salivary amylase acts on starches and converts them to maltose.
Akt is the enzyme which is known as protein kinase B. Its scientific term is thymoma viral proto-oncogene and its particular job is to help promote cellular revival.
Shape. When an enzyme is overheated the bonds between molecules that make up the enzyme breaks, this changes the shape of the enzyme's active site. And as the enzyme is highly specific and would only work on one substrate which fits its active site, the enzyme will be totally denatured and won't activate anymore if it loses its shape.
A very low pH can break the hydrogen bonds in an enzyme which causes the shape of the enzyme to change shape making the enzyme unable to do it's job. This is called "denaturation" However some enzymes such as pepsin only work in a low pH (pepsin works best in a pH of about 3) so it does depend on the enzyme.
In the small intestine where enzymes from the pancreas and small intestine finsh the job
enzyme-substrate complex
Enzymes are protiens. If you get the balance of pH or temperature outof wack, you can change the shape of the enzyme. Changing the shape of the said enzyme damages the protein, so it cannot do its job. This is called denaturing.
in an enzyme-substrate complex, the enzyme acts on the substrate .
An enzyme is a protein
The active site is part of an enzyme, which is used to help facilitate chemical reactions. In particular, the active site is the part where that reaction occurs.