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How might an amino acid change at a site distant from the active site of the enzyme alter the enzyme's substrate specificity?
An amino acid change distant from the active site can impact the enzyme's conformation and flexibility, leading to changes in the active site shape and size. This can alter how substrates bind to the active site, affecting substrate specificity. Additionally, changes in distant amino acids can cause conformational changes that transmit through the protein, ultimately affecting enzyme-substrate interactions.
Altering the three-dimensional structure of an enzyme might?
prevent the substrate from binding the enzyme's active site
Suppose that enzyme X catalyzes a reaction that involves the breakdown of a molecule. The product of this reaction is an amino acid. What molecule is the enzyme breaking down?
it might be a protein.. since proteins are polymers of various amino acids..
Suppose that the amio acids that make up an enzyme's active site are changed how might this affect the enzyme?
Changing the amino acids in an enzyme's active site can alter the enzyme's shape, potentially disrupting the enzyme-substrate interactions crucial for catalysis. This alteration may result in reduced enzyme activity or even loss of function. The specificity and affinity of the enzyme for its substrate could also be affected, impacting the overall efficiency of the catalytic reaction.
How might amino acid change affect the enzyme?
The pKA of enzyme affects its ionization which could alter enzyme activity. For pH < pKa, the value of vmax is constant and that for pH > pKa, vmax decreases; ie. enzyme activity starts to decline.
What are several different situation in which an enzyme might lose its specific shape?
An enzyme can lose its shape (tertiary structure) through many ways. Some of these include: pH change, increased heat, or change in ionic strength of the solution (increasing or decreasing salt levels).
Can changing just one nucleotide in a gene change the shape of a protein?
If shape of a protein is changed its function is altered. This might change or stop a particular biochemical pathway in which that enzyme was critical. Specific 3D shape of each protein is very essential for its function. Change in shape of proteins is caused by a mutation in the DNA.
What is a protein kinase?
a protein kinase is a protein that activates another protein. typically through phosphorylation. they often consists of two domains, one that phosphorylates, and one that regulates the phosphotransferase activity.
How does boiling an enzyme effects its activity?
As the enzyme gets boiled, the extra heat breaks the bonds that make up the enzyme. This changes it's shape. When an enzyme lose4s it's shape, shape of active site, it loses its specificity, not allowing it to bind to the substrate. This decreases the rate of the reaction until it's completely denatured.
What is client specificity?
"Client specificity" is simply a fancy way to say "something that is specific to or for this client". For example, in medication administration nurses practice "patient specificity" when the nurse conducts conducts med checks that it is the right patient, right medication, right time, etc. In another arena, documentation building you might have "client specificity" in tables and tasks. See the related links section for one website.
How might an error during transcription affect protein that is produced?
The protein might be unable to function.
How might an error during transcription affect the protein that is produced?
The protein might be unable to function.
