Both tried to get rid of people they thought of as bad for society. Salem focused on witches, while th Inquisition dealt with supposed heretics and Jews. One big difference between the two was that in Salem, the accusations ccame from girls believed to bewitched and the accusations in the Inquisistion came from completely normal people and the government. The second large difference is the death tolls. Salem's was 24 and the Inquisition number in the tens of hundreds. The third is execution. It was hanging in Salem and burning in the Inquisition.