Troponin controls the position of tropomyosin on the thin filament, enabling myosin heads to bind to the active sites on actin.
calcium ions, troponin, and tropomyosin
cross bridge cycling ends when sufficient calcium has been actively transported back into the SR (to allow calcium to unbind from troponin)
The tropomyosin molecule blocks the active sites of the actin. Troponin is a molecule that is bound to the tropomyosin. Troponin needs CA+ (calcium ions) to bind to it in order to rotate the tropomyosin molecule and expose the actin molecules for the myosin heads to interact for muscle contraction.
the major intracellular ion in crossbridge formation is what
cross bridge formation "Excitation-contraction coupling" connects muscle fiber excitation to the muscle fiber contraction (cross bridge formation). During contraction, myosin heads form cross bridges many times-with each cross bridge generating a small amount of tension in the muscle fiber.
cross bridge formation "Excitation-contraction coupling" connects muscle fiber excitation to the muscle fiber contraction (cross bridge formation). During contraction, myosin heads form cross bridges many times-with each cross bridge generating a small amount of tension in the muscle fiber.
The actin binding sites are exposed
cardiac troponin I tests measure only cardiac troponin; tests for cardiac troponin T may cross-react with troponin found in other muscles and give positive or increased results in the absence of heart damage.
Acetylcholine binds to sarcolemma; sarcolemma then T-tubules depolarize; Ca++ released from terminal cisternae travels along SR, is release into sarcoplasm, then binds to troponin to unblock tropomyosin binding sites allowing cross-bridge formation (i.e., myosin heads bind to actin).
Acetylcholine release is necessary for skeletal muscle contraction, because it serves as the first step in the process, enabling the subsequent cross-bridge formation. A muscle's ability to contract depends on the formation of cross-bridges between myosin & actin filaments. A drug that blocks acetylcholine release would interfere with this cross-bridge formation and prevent muscle contraction
Actin changes shape.
cross bridge formation "Excitation-contraction coupling" connects muscle fiber excitation to the muscle fiber contraction (cross bridge formation). During contraction, myosin heads form cross bridges many times-with each cross bridge generating a small amount of tension in the muscle fiber.