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It is 580 miles taking this route:

  1. Take I-65 SOUTH, from the Chicago area, to I-465 EAST, via I-865 EAST (at EXIT 129 off I-65 in INDIANA).
  2. Take I-465 EAST (& SOUTH), around INDIANAPOLIS, to I-74 EAST to CINCINNATI at EXIT 49.
  3. Take I-74 EAST to I-275 SOUTH to Kentucky at EXIT 5 off I-74 in OHIO.
  4. Take I-275, around CINCINNATI, to I-75 SOUTH to LEXINGTON at EXIT 85 in northern KENTUCKY.
  5. Take I-75 SOUTH to I-40 EAST to ASHEVILLE, via I-640 around KNOXVILLE, Tennessee.
  6. Take I-40 EAST to TN-66 to GATLINBURG SEVIERVILLE and PIGEON FORGE at EXIT 407; follow signs to TN-66 SOUTH to GATLINBURG.
  7. Take TN-66 SOUTH to U.S. 441 SOUTH to GATLINBURG.
  8. Take U.S. 441 SOUTH to GATLINBURG.
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Q: How far is Gatlinburg Tennessee from Chicago Illinois?
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