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400 miles taking this route:

  1. Take PA-283 WEST (towards HARRISBURG), from Lancaster, to I-76 Pennsylvania TURNPIKE (toll road), near Harrisburg; follow signs to I-76 WEST to PITTSBURGH (EXITS 242-2).
  2. Take I-76 Pennsylvania TURNPIKE (toll road) - WEST to I-70 WEST to WASHINGTON, PA and COLUMBUS, OH at EXIT 75 (the NEW STANTON exit).
  3. Continue on I-70 WEST to Columbus, OH, via I-470 WEST(EXIT 5A off I-70 in WEST Virginia) to bypass WHEELING, WV.

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