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About 169 miles if you use the Natchez Trace Parkway, but the downside is the speed limit is only 50 mph.

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13y ago
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6y ago

The driving distance from Houston, Texas to Tupelo, Mississippi is 630 miles via I-10 E per MapQuest. The driving time per MapQuest is 9 hours and 51 minutes.

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6y ago

120 miles

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6y ago

145 miles

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Q: How far is it from Houston Mississippi to Tupelo Mississippi?
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