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How is norepinephrine removed from the synapse?

Updated: 8/21/2019
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Q: How is norepinephrine removed from the synapse?
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What effect does amphetamines have on norepinephrine?

Amphetamines are psychostimulant drugs of abuse and include methamphetamine, amphetamine and ecstacy or MDMA. Amphetamine drugs can effect norepinephine in several ways. Initially amphetamine drugs will cause a massive release of all monoamine neurotransmitters (dopamine, serotonin and norepinephrine) from the vesicles inside the presynaptic cleft of a neuron. Furthermore, amphetamine and methamphetamine (not MDMA) are very structurally similar to norepinephrine and can substitute, or move through, the norepinephrine transporter (NET) which regulates the amount of norepinephrine in the synapse. This can lead to dysregulation of the transporter so that it no longer functions properly. This can happen in several ways including internalization of the transporter inside the presynaptic cleft and/or phosphorylation of the transporter, which can essentially shut it off. This means that there is more norepinephrine in the synapse, which can bind to norepinephrine receptors and lead to the subjective (feeling), physiological, behavioral and neurobiological effects of amphetamine drugs.


How Neurotransmitter molecules are removed from a synapse by?

Being broken down by enzymes and being reabsorbed by the presynaptic neuron.


What is the junction point between neurons?

A synapse is the junction or a point of close contact between two neurons.


What is the name of the region where two neurons are in done contact is known as?

synapse is that junction through which impulse can be transmitted from one neuron to another.


What is the space between two adjacent nerve cells?

its known as the synapse. Through the synapse is where impulses travel from brain cell to brain cell.


Space between nerve cells is called?

Are you meaning between the buttons of the first nerve cell and the dendrites of the second one? If so, then it is called the synapse or synaptic cleft!


Neurons connect together at a?

Synapse Synapse


What is the plural of synapse?

The plural of synapse is synapses.


What is a synapse and how is information transmitted at the synapse?

A synapse is the gap between two neurones where messages can be sent.


Does cocaine effects the nervous system?

It is a norepinephrine reuptake inhibitor. Norepineprhine is a stimulating neurotransmitter. It makes you feel up, energetic, and hyperactive. It also increases your heart rate and blood pressure. When norepinephrine is released from nerve cells in the synapse to send a signal on to the next nerve cell, there is a reuptake pump that removes the norepinephrine to cut the signal off. This keeps the pathway from firing to much or too long and preserves the norepinephrine for future use. Cocaine blocks the reuptake system and makes the stimulating stronger and last longer. However it that means that you also deplete your supply of norepinephrine and "crash". This makes you feel tired. So you keep wanting more cocaine to get back to that good (high) feeling, but because you have used up the norepinephrine you never quite reach it. That makes cocaine very addictive.


What type of synapse uses neurotransmitter?

Chemical Synapse


What is the connection between neurons called?

A synapse.