3 hours and 6 minutes is the shortest route that Google Maps could come up with, which is a 149 mile drive through Southern Washington, although you will be able to see the Oregon border when passing the Columbia River.
Alternatively, if you wanted to cycle, a 104 mile course is available for bicycles, However, this would be an 11-hour trip by bike, or 32 hours by foot. Driving is recommended, although possibly less scenic.
about 2 hours
how long would it take to hike mount st Helens
19 hours
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