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This depends on the size of the aspirin, and what exactly is meant by "at one time".
If you mean how many can be ingested in parallel, that would depend on the size of the esophagus relative to the size of the individual tablets, caplets, gelcaps, or whatever form of aspirin being ingested.
If you mean how many can be physically contained by a human (I'm assuming you are concerned with humans here, which may not be correct) then the answer would depend on the size of the stomach, previous stomach contents, and how much water was necessary to swallow the aspirin, among other things.
If you mean "How many aspirin can be safely taken at one time" you should probably read the label on the bottle, and consult your physician.
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