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About 8h10 with one change (at Dresden, Nürnberg, or Regensburg).

The journey can also be done in about 6 hours by travelling to Nürnberg by train (journey time: 2h08) and from there taking an express bus (reservation required) to Prague (journey time: 3h37).

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11y ago
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Q: How many hours by train from Frankfurt to Prague?
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