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The distance from Gastonia, NC to Myrtle Beach, SC is 226 miles. Leaving Gastonia, take I-85 toward Charlotte. Turn south on I-485 and follow it to i-77 south. continue on I-77 to SC 34 East. follow SC 34 E to Baldwin Ave. Follow Baldwin Ave. south until it becomes Hwy 601 South. Follow 601 to I-20 east. continue on I-20 east to Hwy 76 west of Florence, SC. Take Hwy 76 east to 576 near West Marion. SC 576 turns into Hwy 501, continue on this road to Myrtle Beach.
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