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The driving distance from Sioux Falls, South Dakota to Des Moines, Iowa is 280 miles via I-29 S per MapQuest. The driving time per MapQuest is 4 hours and 9 minutes.

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6y ago
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6y ago

The driving distance from South Haven, Michigan is 439 miles via I-80 W. The driving time is 6 hours and 33 minutes.

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9y ago

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Q: How many miles from Des Moines Iowa to South Dakota?
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