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It is thought that every 1:2000 Caucasian births results in someone who is genetically 'alpha-1 antitrypsin deficient'. This puts the potential deficient population in the US at about 100,000 even though only a fraction of that number has been identified.
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How many Americans lack alpha-1-antitrypsin?
The number of Americans with this deficiency is relatively small, probably no greater than 70,000
How many people have alpha 1?
It's not such a simple answer I'm afraid. If you are asking how many people have 2 deficient genes for the production of Alpha-1 Antitrypsin in the liver (and other parts of the body) then the answer is between 1 in 2000 live Caucasian births to one in ever 10 or 20,000. Right now in the USA and Canada there are roughly 10,000 identified alphas and estimates of another 90,000 undiagnosed or misdiagnosed. It is the number one autosomal recessive genetic condition humans face. As with many such conditions, having the deficiency is not a disease in and of itself. Being deficient simply means that you any or all of the skin, liver and/or lung diseases that can occur because of the deficiency.
How many people have alpha-1 antitrypsin deficiency?
It's not such a simple answer I'm afraid. If you are asking how many people have 2 deficient genes for the production of Alpha-1 Antitrypsin in the liver (and other parts of the body) then the answer is between 1 in 2000 live Caucasian births to one in ever 10 or 20,000. Right now in the USA and Canada there are roughly 10,000 identified alphas and estimates of another 90,000 undiagnosed or misdiagnosed. It is the number one autosomal recessive genetic condition humans face. As with many such conditions, having the deficiency is not a disease in and of itself. Being deficient simply means that you any or all of the skin, liver and/or lung diseases that can occur because of the deficiency.
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