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If Vitamin D is very low and urine calcium very high 750 and so is pth what does this mean?
Wiki User
∙ 11y ago
In most cases, high calcium, high PTH, and low vitamin D point to Parathyroid Disease. This is normally caused by a benign parathyroid tumour, which will not go away on its own and must be removed.
PTH stands for Parathyroid Hormone. The normally rice-sized parathyroid glands are not actually related to the thyroid itself (they just live next to it), and are responsible for regulating your calcium levels. This is all that they do. The four parathyroid glands act as a sort of thermostat system, controlling the amounts of calcium in the body. The parathyroids are very sensitive to calcium levels, "turning on" (releasing PTH) when they detect your calcium going low, and "turning off" (not releasing PTH) when they detect your calcium going high. They're normally quite precise in detecting and reacting to calcium.
Calcium is crucial for your electrical systems - nervous system, brain, muscle impulses, etc. - to function normally. Because calcium is so critical, a primary function of your bones is to maintain calcium reserves, acting as a sort of calcium "bank" from which you can withdraw calcium whenever you need it. When your parathyroids detect your calcium going low, the release of PTH tells your bones to release their calcium, and when your calcium starts to increase, the parathyroids stop PTH, telling your bones to start storing calcium. This back and forth should normally happen many times per day, keeping the calcium available to your brain, muscles, heart, and nervous system inside a very precise range.
A parathyroid tumour causes one (or in rare cases, more) of the four parathyroid glands to overproduce PTH, essentially becoming stuck in the "on" position. Your bones get a constant signal to release calcium, which causes a lot of problems:
- Your bones essentially break down, as they constantly dissolve far too much of their calcium into your blood stream. This causes osteoporosis - even in young people.
- Since vitamin D is what your body uses to help absorb more calcium from your diet, your body detects all of this extra calcium and puts the brakes on the vitamin D to protect itself from absorbing even more of it. This vitamin D deficiency brings a bunch of its own problems.
- The overload of calcium can become too much for your electrical systems, which can start to go out of whack, causing depression, memory loss, and other brain symptoms, heart symptoms, and musle cramps, among other things. Excess calcium is very hard on your body.
- Your kidneys will have a hard time dealing with all of this extra calcium, which can cause kidney stones or other kinds of kidney damage over time.
- Excess PTH and calcium is particularly bad for a pregnant woman. The baby's parathyroid glands, detecting high calcium, can fail to activate or even fail to develop at all - which can bring an extremely elevated risk of miscarriage or life-threatening problems if there is a live birth.
High calcium is NEVER normal, and it should NOT be watched to "see if it goes down." It will not. If your doctor tells you this, immediately find a new doctor.
If you have a parathyroid tumour (which is almost always benign - NOT cancer), it must be removed or your symptoms and the damage it is doing to your body will only get worse.
You can find much more information at www.parathyroid.com
Wiki User
∙ 11y ago
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