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If you had to have the equivalent of 4 pints transfused then something significant has happened to make you lose some of your blood. So the answer is yes. However, if you are referring to what risk you may be open to; the blood supply is extremely safe in the US and blood transfusion is extremely common procedure so any risk is minimal.

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Q: If you have to get 4 pints of blood in your body is that bad?
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