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its quite intresting to kno dat in a single cell the length of DNA integrated is about 2metres or more. so to accomodate dat much length of smething it needs to b wrapped. it can can b thought of packing a heap of clothes in a small suitcase. So it has to be compacted to a level of packing called nucleosomes.
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Most notably, the Histone proteins which, along with Dna, form the core of the 10 nm fibers.
Protein involved in DNA condensation. In most eukaryotes, the chromosomal packing involves the wrapping of DNA around a core of histones to form nucleosomes. Adjacent nucleosomes are packaged together via Histone 1 and nucleosomes are organized into a 30 nm chromatin fiber. DNA condensation takes place as cells enter mitosis or when germ cells enter meiosis.
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Nucleosomes are the basic repeating units of chromatin which is a combination of DNA and proteins that make up the content's of a cell's nucleus. Nucleosomes are made of a histone octamer which is comprised of two of the following histones: H2A, H2B, H3, and H4. The histone octamer is bound and wrapped around approximately 146 base pairs of DNA and an additional H1 histone is added and is wrapped around 20 more base pairs.
A nucleosome is a complex made of 8 histones with DNA wrapped around it approximately twice. Histone 1 probably serves to help stabilize the further wrapping of the nucleosomes into a solenoid. All of this helps to get 6 feet of DNA in a cell much less than a millimeter across.
its quite intresting to kno dat in a single cell the length of DNA integrated is about 2metres or more. so to accomodate dat much length of smething it needs to b wrapped. it can can b thought of packing a heap of clothes in a small suitcase. So it has to be compacted to a level of packing called nucleosomes.
A Histone Core is a group of Histone Proteins, mainly used in eukaryotes to package DNA strands into Nucleosomes. (Think of it like a spool for the DNA to wrap around, to be easily stored on a shelf)
This is called a Chromatid. For example a Human Chromosome that is expanded at 32,000 micrometers long will loop {supercoil} around Histones and end up being just 6 micrometers long!
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A Histone Core is a group of Histone Proteins, mainly used in eukaryotes to package DNA strands into Nucleosomes. (Think of it like a spool for the DNA to wrap around, to be easily stored on a shelf)
HistonesHistones are proteins that aid in the organization of DNA into chromosomes. There are four types of histones found in chromatin: H2A, H2B, H3, and H4. Two of each histone comprise a protein core, a nucleosome, which DNA wraps around twice. What results is a "bead on a string" model in which the nucleosomes are the beads and the linker DNA binds them together. Another characteristic of histones are the protein tails that extend outward from the "bead." The tails and the degree of their acetylation is an important factor in gene expression. See related links and images below.
core, cord, cold, colt
MARE MORE CORE CORD COLD COLT MARE MORE CORE CORD COLD COLT
Most notably, the Histone proteins which, along with Dna, form the core of the 10 nm fibers.
Core Cord Cold Colt