Is there scientific evidence supporting the use of medical cannabis for muscle spasms?

Answer 1

​Yes, there is scientific evidence suggesting that medical cannabis can help alleviate muscle spasticity, particularly in conditions like multiple sclerosis (MS). Various studies and reviews have explored the efficacy of cannabinoids—active compounds in cannabis—in managing spasticity symptoms.​

Patient-Reported Outcomes:

Research indicates that individuals with MS using cannabis-based products are more likely to report improvements in spasticity compared to those taking a placebo. A review by the American Academy of Neurology (AAN) found that patients reported relief from muscle stiffness and spasms when using these products. ​

Multiple Sclerosis Society UK

Clinical Trials and Reviews:

Moderate evidence suggests that cannabinoids, such as nabilone and nabiximols, may reduce spasticity. However, these benefits are often modest and primarily based on patient self-reports rather than objective clinical measures. For instance, a systematic review noted that while patients experienced some relief, the therapeutic effects were limited and accompanied by an increased risk of adverse events. ​

Cleveland Clinic

Limitations and Considerations:

It's important to note that while patient-reported outcomes are positive, clinician-measured assessments sometimes do not show significant improvements. Additionally, the therapeutic window for cannabinoids is narrow, meaning the balance between beneficial effects and side effects can be delicate. Therefore, while medical cannabis may offer relief for some individuals with muscle spasticity, its use should be carefully considered and monitored by healthcare professionals. ​

In summary, scientific evidence supports the potential of medical cannabis in alleviating muscle spasticity, especially in MS patients. However, the effectiveness can vary, and further research is needed to fully understand its benefits and risks.