It depends on how you mean the question.
If you are referring to the city of Columbus, NO, it is a city in Ohio.
If you are referring to the explorer, YES, Christopher Columbus is buried in the floor of the Seville Cathedral in southern Spain.
Columbus was from Spain.
Columbus appealed to Queen Isabel I of Spain.
Columbus worked for Spain.
Christopher Columbus's sponsor was Spain
Columbus was a native of Spain and he lived in Spain all of his life.
how was Columbus mistaken about the lands he claimed for Spain
Christopher Columbus accidentally discovered America for Spain.
Spain funded Christopher Columbus's voyages to the Americas.
Christopher Columbus was born in Spain, then he and his family moved to Italy.
the indigenous people
Columbus started his voyage in Spain
Columbus left from Spain