You need to look under the vehicle and see if there is a transfer case in the rear of the vehicle (gear box) which will bring the power from the engine to the rear wheels.
The Lexus ES 300 is front wheel drive and the Lexus GS 300 is rear wheel drive
The 2008 Lexus RX-350 has front wheel drive.
The 2012 Lexus CT-200H has front wheel drive.
The 2014 Lexus RX-450H has front wheel drive.
The 2014 Lexus ES-300H has front wheel drive.
The 2012 Lexus RX-450H has front wheel drive.
The 2013 Lexus ES-300H has front wheel drive.
The 2010 Lexus RX-350 has front wheel drive.
The 2010 Lexus RX-450H has front wheel drive.
The 2012 Lexus ES-350 has front wheel drive.
The 2011 Lexus RX-350 has front wheel drive.
The 2014 Lexus CT-200H has front wheel drive.