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No, they are different medications -- vicodin is a narcotic pain killer and penicillin is an anti-biotic. An allergy to vicodin is unreleated to an allergy to penicillin. However, do not use Vicodin if you are allergic to acetaminophen (Tylenol) or hydrocodone.

You should consult with your doctor or pharmacist if you have questions regarding specific Allergies to medications.

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Q: Is a Vicodin allergy related to a penicillin allergy?
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