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In response to below, NO. The latest data we have shows that Inositol Hexanicotinate doe not affect HDL, LDL or TGs at all. It was "presumed" to work, but this has since been disproven. All the articles below are essentially speculation. The FDA should actually pull the drug off the market since the only thing it actually does help is vitamin B deficiency (which is rare). People take it to avoid flushing, but since it doesn't help with lipids at all, it doesn't matter that it avoids flushing - it does this because it's not actually working.
If you want to lower your LDL and TG and raise your HDL, take immediate release niacin (OTC), slow-release niacin (Slo-Niacin - OTC) or extended-release niacin (Niaspan - Rx). Ask your pharmacist for more information.
-the most recent published information I could find upon cursory search is Meyers CD, Carr MC, Park S, Brunzell JD. Varying cost and free nicotinic acid content in over-the-counter niacin preparations for dyslipidemia. Ann Intern Med. 2003;139(12):996-1002.
Yes, based on the open scientific literature it lowers high cholesterol better than does plain Niacin. Basically triglycerides (VLDL) are reduced and HDL is increased (a very good thing). You can expect your total cholesterol to approach a more normal value.
The decrease expected (dTC) from your initial total cholesterol level (TC) varies according to ones' body weight (Wgt) by the equation:
dTC = 0.95(TC) - 0.39(Wgt) - 90 (from Abram Hoffer M.D. Ph.D)
Dr Hoffer notes that total cholesterol levels will rise if the initial level was abnormally low for the patient's body weight (here a negative dTC is an increase).
Supporting data:
"IHN is more effective than niacin in its hypocholesterolemic,
antihypertensive and lipotropic effects"
Welsh AL, Eade M. Inositol hexanicotinate for improved nicotinic acid therapy.
Int Record Med 1961;174:9-15.
"significant lipid-lowering effects of IHN at doses of 400 mg 3-4 times daily"
Dorner V, Fischer FW. The influence of m-inositol hexanicotinate ester on the serum lipids and lipoproteins. Arzneim-Forsch 1961;11:110-113.
Sommer H. Nicotinic acid levels in the blood and fibrinolysis under the influence of the hexanicotinic ester of m-inositol. Arzneim Forsch. 1975;15:1337
"IHN was found to be more effective than niacin in reducing hypercholesterolemia"
El-Enein AMA, Hafez YS, Salem H, Abdel M. The role of nicotinic acid and inositol hexaniacinate as anticholesterolemic and antilipemic agents.
Nutr Reports Int 1983;28:899-911.
"Derivatives of niacin have been examined for their ability to alter lipid levels as well as niacin. It would be advantageous if the niacin vasodilation (flush) were eliminated or removed. The main disadvantage of the niacin derivatives will be cost. Inositol hexanicotinate is an ester of inositol and niacin. In the body it is slowly hydrolyzed releasing both of these important nutrients. The ester is more effective than niacin in lowering cholesterol and triglyceride levels, Abou El-Enein, Hafez, Salem and Abdel (1983). I have used this compound, Linodil, available in Canada but not the U.S.A. (at the time this paper was written) for thirty years for patients who can not or will not tolerate the flush. It is very gentle, effective, and can be tolerated by almost every person who uses it."
From: Niacin, Coronary Disease and Longevity by Abram Hoffer, M.D., Ph.D.
BIAM (a database designed for health professionals) entry:
Alternate Names:
"inositol hexanicotinate"
"inositol hexaniacinate"
"hexanicotinoyl inositol"
"inositol hexanicotinate"
"mesoinositol hexanicotinate"
Trade Names:
Dilcit
Dilexpal
Mesotal
Esantene
Hamovannid
Hexanicit
Hexanicotol
Hexopal
Linodil
Mesonex
Palohex
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Lowering Cholesterol For Elderly?
There are many ways to reduced cholesterol. One can try to eat a low cholesterol diet, eat more fiber, and excercise more. There are also many effective cholesterol lowering drugs available.
Where can I find a list of cholesterol lowering foods?
List for cholesterol lowering foods can be found on websites such as www.webmd.com/cholesterol.../guide/cholesterol-lowering-foods, www.mayoclinic.com/health/cholesterol/CL00002, and foodsthatlowercholesterol.org/
Which herbal remedy is effective in lowering cholesterol?
will savila will be good . also pills of omega 3 could be good for that or at least that's how my mom controlled her cholesterol .
Is lowering cholesterol hard?
No, lowering cholesterol is not that hard. You just need to eat foods with lower levels of cholesterol.
Do any cholesterol lowering drugs contain amphetamines?
No, there is no FDA approved drug for "cholesterol lowering" that contains amphetamines. It has no effect on cholesterol.
What does guggel do?
the gum resin, which contains guggulsterone, a steroid compound. It appears to be effective in lowering blood levels of both total cholesterol and low-density lipoprotein (LDL) cholesterol.
Aside from changing my diet, how may I go about lowering my cholesterol?
There are many ways to lower the cholesterol. The most effective is diet, but next is exercise. Exercise is a very good bet to lower the cholesterol levels in the body.
Are any vitamins effective in lowering cholesterol?
Although vitamins are important for a good healthy body, there is no clear proof that vitamins lower cholesterol. You can eat foods that do prevent and reduce cholesterol, however: http://www.mayoclinic.com/health/cholesterol/CL00002
Can Vitamins Lower Cholesterol?
High cholesterol can be unhealthy and dangerous, often leading to hardening of the arteries and heart disease. Prescription medications can be quite effective when lowering cholesterol, but regular exercise, a well-balanced diet, and the right regimen of cholesterol-lowering vitamin supplements (in addition to medications, or by themselves) may also be effective. Some vitamins showing evidence of lowering serum cholesterol are: Vitamin C, Vitamin B3 (Niacin), and Selenium. Niacin is even prescribed by some doctors to help lower cholesterol. When considering the best course of treatment, it is important to consult with your doctor who can help you decide the best way to lower serum cholesterol, whether by using medication, vitamin supplementation, or a combination of the two.
What are fibric acid derivatives?
Although these drugs are less effective than the statins at lowering total cholesterol, they may be able to lower the low-density lipoprotein (LDL) cholesterol while raising the high-density lipoprotein (HDL) cholesterol.
What is Questran?
It is a cholesterol-lowering drug
What is Colestid?
It is a cholesterol-lowering drug
