Is inositol hexanicotinate effective in lowering cholesterol?

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In response to below, NO. The latest data we have shows that Inositol Hexanicotinate doe not affect HDL, LDL or TGs at all. It was "presumed" to work, but this has since been disproven. All the articles below are essentially speculation. The FDA should actually pull the drug off the market since the only thing it actually does help is vitamin B deficiency (which is rare). People take it to avoid flushing, but since it doesn't help with lipids at all, it doesn't matter that it avoids flushing - it does this because it's not actually working.


If you want to lower your LDL and TG and raise your HDL, take immediate release niacin (OTC), slow-release niacin (Slo-Niacin - OTC) or extended-release niacin (Niaspan - Rx). Ask your pharmacist for more information.

-the most recent published information I could find upon cursory search is Meyers CD, Carr MC, Park S, Brunzell JD. Varying cost and free nicotinic acid content in over-the-counter niacin preparations for dyslipidemia. Ann Intern Med. 2003;139(12):996-1002.

Yes, based on the open scientific literature it lowers high cholesterol better than does plain Niacin. Basically triglycerides (VLDL) are reduced and HDL is increased (a very good thing). You can expect your total cholesterol to approach a more normal value.

The decrease expected (dTC) from your initial total cholesterol level (TC) varies according to ones' body weight (Wgt) by the equation:

dTC = 0.95(TC) - 0.39(Wgt) - 90 (from Abram Hoffer M.D. Ph.D)

Dr Hoffer notes that total cholesterol levels will rise if the initial level was abnormally low for the patient's body weight (here a negative dTC is an increase).

Supporting data:

"IHN is more effective than niacin in its hypocholesterolemic,
antihypertensive and lipotropic effects"
Welsh AL, Eade M. Inositol hexanicotinate for improved nicotinic acid therapy.
Int Record Med 1961;174:9-15.

"significant lipid-lowering effects of IHN at doses of 400 mg 3-4 times daily"
Dorner V, Fischer FW. The influence of m-inositol hexanicotinate ester on the serum lipids and lipoproteins. Arzneim-Forsch 1961;11:110-113.

Sommer H. Nicotinic acid levels in the blood and fibrinolysis under the influence of the hexanicotinic ester of m-inositol. Arzneim Forsch. 1975;15:1337

"IHN was found to be more effective than niacin in reducing hypercholesterolemia"
El-Enein AMA, Hafez YS, Salem H, Abdel M. The role of nicotinic acid and inositol hexaniacinate as anticholesterolemic and antilipemic agents.
Nutr Reports Int 1983;28:899-911.

"Derivatives of niacin have been examined for their ability to alter lipid levels as well as niacin. It would be advantageous if the niacin vasodilation (flush) were eliminated or removed. The main disadvantage of the niacin derivatives will be cost. Inositol hexanicotinate is an ester of inositol and niacin. In the body it is slowly hydrolyzed releasing both of these important nutrients. The ester is more effective than niacin in lowering cholesterol and triglyceride levels, Abou El-Enein, Hafez, Salem and Abdel (1983). I have used this compound, Linodil, available in Canada but not the U.S.A. (at the time this paper was written) for thirty years for patients who can not or will not tolerate the flush. It is very gentle, effective, and can be tolerated by almost every person who uses it."
From: Niacin, Coronary Disease and Longevity by Abram Hoffer, M.D., Ph.D.

BIAM (a database designed for health professionals) entry:
Alternate Names:
"inositol hexanicotinate"
"inositol hexaniacinate"
"hexanicotinoyl inositol"
"inositol hexanicotinate"
"mesoinositol hexanicotinate"

Trade Names:
Dilcit
Dilexpal
Mesotal
Esantene
Hamovannid
Hexanicit
Hexanicotol
Hexopal
Linodil
Mesonex
Palohex
23 people found this useful

How does niacin help lower cholesterol?

Answer . Niacin, also known as nicotinic acid, is vitamin B3. It occurs naturally in plants and animals and is also added to many foods as a vitamin supplement. Niacin also blocks the production of cholesterol in the body.. Niacin is used to reduce levels of LDL (or "bad") cholesterol, total c ( Full Answer )

How do you lower cholesterol?

First, make dietary changes. Eat more fish containing omega 3 fatty acids, such as salmon or sardines (but please be careful with fish, everyday eating fish gets riskier and riskier with the conditions of our coastal waters). Eat foods with monounsaturated fats, such as olives, olive oil and avocado ( Full Answer )

How do you lower your cholesterol?

There are some simple ways to lower your cholesterol : . Eating a healthy diet (avoid unnecessary carbohydrates, and try to avoid hydrogenated fats, whether they be from animal or vegetables. Avoiding foods with natural cholesterol like meat products will actually make lowering cholesterol harder ( Full Answer )

How do I lower my cholesterol?

There are a couple of things that you can do to lower cholesterol . The most common solution that the current medical establishment currently uses is statin drugs. Unfortunately these cause many people to have some rather harsh side effects. Unless your cholesterol is off the charts and require imm ( Full Answer )

Best way to lower cholesterol?

\n. \n Answer \n. \nrunning every morning,working up quiet a bit of sweat will surely give a good results. Eat oil fat and add dietary fiber - like in oat flakes. Add Acai Berry drink or capsules.

How can you lower your cholesterol naturally?

Thankfully there are natural ways to help lower your cholesterol without reducing to medication. You want to be eating foods that have plant sterols in them like fruits and veggies. Recently my mom told me about a nutritional beverage that she has been drinking. After drinking it for awhile, she g ( Full Answer )

What is inositol?

Inositol, also known as phytic acid, is a phytochemical found in bran from corn, oats, rice, rye and wheat, nuts, soybeans and soy products (tofu, soy milk, edamame, etc.). It may retard cancer cell growth and work as an antioxidant. However, non-ruminant animals can't access the inositol in these s ( Full Answer )

What is the difference between inositol hexanicotinate and inositol hexaniacinate?

There is no difference. These are but two of many names for the same compound. Here are a couple of lists all the names (that I know of) for "IHN"... Alternate Names: "flush-free niacin" "inositol hexanicotinate" "inositol hexaniacinate" "hexanicotinoyl inositol" "inositol hexanicotin ( Full Answer )

Will soup help lower cholesterol?

Eating the right kind of soup can help lower cholesterol. Avoidsoups with cream, red meat, cheese, and any egg products.

Is flush free niacin inositol hexanicotinate the same as long acting niacin?

No. Flush-free niacin is niacin (nicotinic acid) that has been encapsulated to make it dissolve slowly. It is sold as "Niaspan" and is a prescription drug. Inositol hexanicotinate can be thought of as an inositol molecule (a hexa-alcohol) to which six niacin molecules have been attached as esters. W ( Full Answer )

Are Cholesterol lowering drugs safe?

Most all drugs have the possibility of producing negative effects. I have a fellow professor at the college I teach at that was on lipitor. When they changed his medication, he developed cancerous tumors within the rib cage. However, because the cancer was not genetically produced, they were able to ( Full Answer )

How can you lower your cholesterol without medication?

High cholesterol can be lowered somewhat by exercise and somewhat by avoiding saturated and trans fats in the diet. Foods containing high fiber, especially soluble fiber like that found in abundance in oat bran, will also lower cholesterol. Even a high fiber drink like Metamucil will soak up chole ( Full Answer )

Why lower cholesterol?

An abundance of low-density lipoproteins (LDLs) is dangerous because it contributes to a condition called atherosclerosis, or plaques in the coronary arteries. High LDLs causes deposition of the fatty streak inside of the coronary arteries is easily damaged by high LDLs and other factors such as hig ( Full Answer )

A list of foods that lower cholesterol?

Here are the top 10 . Olive oil . Walnuts . High fiber food such as oatmeal or oat bran . Tomato . Garlic . Flaxseed . Avocado . Fish . Blueberries . Dark chocolate Hope this helps!

What can you do to lower cholesterol in 24 hours?

It would be nearly impossible to lower cholesterol in 24 hours but the best way to lower cholesterol is to eat more fresh fruits and vegetables, nuts--in moderation, exercise in moderation and take necessary medication.

What are the effects of Cholesterol?

· Angina · Coronary heart disease · Heart arrhythmias -- an irregular heart rhythm · Transient ischemic attack ( TIA , or "mini" stroke ) · Heart attack · Stroke · Peripheral artery disease · High blood pressure .

How to lower cholesterol?

You can bring your cholesterol levels down through diet and exercise. Keep a heart healthy diet. There are plenty of tips available on the Internet to help you choose the right foods. You should also exercise every day for at least 30 minutes. A brisk walk will do, if you are not able to do more. ( Full Answer )

How fiber lower cholesterol?

Fibers reduce absorption of fats and glucose in the body, thereby lowering high density cholesterol and increasing low density cholesterol. They also add bulk to feaces.

Is fiber lower cholesterol?

Fiber helps the body collect and remove cholesterol Dietary fiber binds bile, blood cholesterol, and fatty acids together into a bulky package of waste. Because it makes stool bulkier, fiber encourage easier bowel movements, and assist in the transport of cholesterol out of your body.

What food lowers cholesterol?

soup Pine-nuts are said to lower cholesterol while the consumption of meat should be avoided. Fish, however, seems to be beneficial too.

What is the fastest way to lower cholesterol?

Immediate changes in what you eat can begin to bring down cholesterol levels. Reduce the fats and foods cooked in fats (i,e. most fast foods) and eat more fruits and vegetables. You must also begin a committed program of exercise; walking is one of the best ways to rid the body of excess fat, which ( Full Answer )

How do you lower cholesterol naturally?

Thankfully there are natural ways to help lower your cholesterol without reducing to medication. You want to be eating foods that have plant sterols in them like fruits and veggies. Recently my mom told me about a nutritional beverage that she has been drinking. After drinking it for awhile, she g ( Full Answer )

Will not eating cholesterol lower your cholesterol?

No, actually, it will not. Your body needs cholesterol to do a great number of things, and if you are not getting it from the foods you eat, your body will make its own. There is absolutely nothing wrong with cholesterol. It has gotten a bad name for a number of reasons, none of them legitimate.

What drinks help lower cholesterol?

Drink plenty of water, herbal teas, green tea, and some vegetable juices. Drinking fluids will aid your liver in detoxing your body. Fruit juices raise blood sugar too quickly and may cause an insulin rush which will cause a rise in blood fats or triglycerides and possibly cholesterol. It is better ( Full Answer )

What herbs lower cholesterol?

Some herbal therapies include alfalfa (Medicago sativa ), Asian ginseng (Panax ginseng ), and fenugreek (Trigonella foenum-graecum )

What foods are best at lowering cholesterol?

Foods that are good at lowering cholesterol include, but are not limited to, oatmeal, fruits, vegetables, and whole grains. Foods rich in fiber help the body rid itself of cholesterol.

How can you lower your high cholesterol?

There are many treatments available for lowering cholesterol levels including low-fat and low-cholesterol diets, regular exercise, and prescription medications.

What are some tips for lowering your cholesterol?

Some tips to lowering cholesterol, one of the most important ones is to start eating healthy and cutting our a lot of red meats and fat. Make sure you get plenty of vegetable and if possible start a exercise program.

What do you do to lower your cholesterol?

One of the best ways to lower your cholesterol is to change your diet. Avoid saturated fats, increase your fibre intake, eat more fruits and vegetables, eat fish that contain omega-3's two or three times a week and increase your physical activity!

How can you safely and effectively lower your cholesterol?

You can lower you cholesterol by eating healthier foods. Foods rich in soluble fiber such as oatmeal, bran, and bananas help. Also helpful are foods with omega-3 fatty acids, such as fish. Another good food to eat is nuts, such as almonds and walnuts.

How may you lower your cholesterol levels?

One way to lower cholesterol levels is good old fashioned exercise and watching what you eat. Some foods said to help lower your levels are Fish, nuts, plant sterols(added in foods) and best of all whole grains and oatmeal.

How can you lower you cholesterol without drugs?

Cholesterol-lowering supplements without medication:If your doctor prescribes medication to reduce your cholesterol, take it as directed while you continue to focus on a healthy lifestyle. Healthy lifestyle choices, dietry supplements and cholesterol-lowering products are certain measures that can ( Full Answer )

How does probiotic yogurt lower cholesterol?

Several scientific studies have been carried out to test whether yogurt consumption reduces cholesterol levels or not, but so far the results are not consistent. There are at least two ways in which bacteria could affect serum cholesterol. As the bacteria in the lower intestines ferment, they p ( Full Answer )

Does giving blood lower cholesterol?

No is the simple answer. Cholesterol is for the most part evenly distributed in the blood and therefore when donating blood you take cholesterol with the blood. Your body will have a lower MASS of cholesterol but the CONCENTRATION of cholesterol has not changed, which is what is important for you I ( Full Answer )

Can glutens help lower cholesterol?

Some studies show that gluten (especially in whole grains) does lower cholesterol, some of these studies were done on animals. But this comes with the caveat that one is not gluten intolerant or a celiac (two different but very common conditions). In such cases, gluten will, in fact, raise cholester ( Full Answer )

Does white wine lower cholesterol?

Yes, as does red wine, beer, and distilled spirits (whiskey, gin, tequila, etc.) It's the alcohol that raises the good cholesterol (HDL) and lowers the bad cholesterol (LDL).

Which types of food lower cholesterol?

To lower your cholesterol one should eat a diet of low fat and high fiber foods.Buy your favorite canned or dry beans, fresh fruits, whole grains, vegetables, and vegetable juice.

What are good foods to lower cholesterol?

High fiber foods can be good to reduce cholesterol. Oatmeal and Oat bran are good examples. Fish and Omega-3's are also excellent. Nuts are also good at this job.

How to lower my cholesterol?

There is only one way to lower cholesterol. You should go to thedoctor and get put on cholesterol pills.

How can i lower my cholesterol without pills?

Other than changing your diet and exercising, you can also tryherbal extracts. Artichoke leaf extract and Milk Thistle (relatedplants) have been found to be effective in lowering highcholesterol. They also said to benefit people who have type 2diabetes. Also these are said to have also been fo ( Full Answer )

What can you do to lower your blood cholesterol levels?

Exercise more and otherwise be more physically active, eat lessmeat and more fish and vegetables, eliminate hydrogenated vegetableoil from your diet, reduce saturated fats from your diet, increaseunsaturated fats in your diet. Also consider supplementing your diet with Omega-3 and as a lastresort ge ( Full Answer )

Can Red Grapefruit Lower Cholesterol?

Those taking statins (and many other medications) should avoidgrapefruit as it changes the rate certain drugs are absorbed intothe bloodstream. With several cholesterol lowering drugs likesimvastatin, for example, grapefruit juice can boost the level ofstatin to potentially dangerous levels. However ( Full Answer )