As with most overdrive-equipped vehicles, the most potential for damage is when the transmission is frequently shifting into, and out of, overdrive. This would most likely occur during some city driving, winding rural roads, or hilly areas with a lot of transitions from uphill to downhill, and visa-versa. Unless you notice it kicking into and out of overdrive often, it's probably not a problem to leave it on.
The 2004 Dodge Durango has rear wheel drive.
The 2002 Dodge Durango has rear wheel drive.
The 2005 Dodge Durango has rear wheel drive.
The 2008 Dodge Durango has rear wheel drive.
The 2013 Dodge Durango has rear wheel drive.
The 2001 Dodge Durango has rear wheel drive.
The 2006 Dodge Durango has rear wheel drive.
The 2009 Dodge Durango has rear wheel drive.
The 2003 Dodge Durango has rear wheel drive.
The 2012 Dodge Durango has rear wheel drive.
The 2011 Dodge Durango has rear wheel drive.
The 2007 Dodge Durango has rear wheel drive.