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i do not see why not since it would still be somewhat purebred with 2dog mixes in it,as long as the female dog is healthy enough to have a litter,but when breeding a dog best advice i can give is make sure the female is at least 2 years of age and do not breed her more then once a year.

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Q: Is it okay to breed a maltipoo with another maltipoo if so any advice?
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