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It completely depends on the type of defect;if it is X recessive or if it is not X recessive at all.

For example:

Consider two healthy sisters;one of them with chromosomal defect that doesn't show it:

Aa&AA and the father Aa:

Aa*Aa:1/2 Aa,1/4 aa,1/4AA

AA*Aa:1/2AA,1/2Aa

As we see the first sister may have a defective child but the second one may never have a defective child.

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Q: Is it possible for sisters to have babies from the same brother and the babies to have the same physical defect?
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