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Excedrin contains acetaminophen, caffeine, and aspirin. All three of these will not interact with Atenolol.

HOWEVER, taking two Excedrin is the same as drinking two cups of coffee back to back. Atenolol is usually prescribed to decrease blood pressure and pulse to normal levels. It may be counter-productive to be increasing your intake of caffeine while on Atenolol. It is something you should discuss with your doctor.

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Q: Is it safe to take excedrin while taking Atenolol?
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