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My Dr has had me on Opana er for quite some time & over the past several months I've mentioned to him that the Opana er doesn't seem to last the full 12 hours that it is supposed to & I end up taking my 2nd daily dose earlier than 12 hrs after my first so when I awake in the morning I am in pain & also feel "hungered" which my Dr suggests is withdrawals since it has been longer than 12 hrs since my last dose.

He added 10 mg of Methadone per day for me to take, and I take it once daily now. It hasn't really decreased pain, which is mostly manageable with my Opana, but it has taken away that "hungover" feeling I was having & now I can wait the full 12 hours between doses so I am not withdrawing in the morning. It has been about 3 months since the change & boy what a difference it has made. I'm finally able to stay at an even-keel with my pain & also my opiate withdrawal feeling. My Dr has had me take blood tests twice since adding methadone & he's OK with what he's seeing.

Hope this helps.

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13y ago
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12y ago

No!!! Do not mix those two drugs. I knew a girl that died from mixing exactly that

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Q: Is it safe to use methadone and opana together?
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