Real in the sense that "such things exist" ... yes.
Real in the sense that "it really is a mysterious ancient artifact" ... no. Most of the known examples have been shown to be from the 19th century or later, probably manufactured in Europe.
because its made of crystal
Legend of the Crystal Skull happened in 2007.
it is a skull of a alien
Crystal
The Production Budget for Indiana Jones and the Kingdom of the Crystal Skull was $185,000,000.
The Crystal Skull - 1996 VG was released on: USA: 1996 (PC version)
It's called Crystal Head vodka, I linked a webpage.
It is the shape of our human skull. ^_____^ Also goto www.crystalskull.com
The crystal skull entity grants her the desire to know everything, overloading her mind and causing her to disintegrate.
Nope.
The Lost World of the Crystal Skull - 2008 TV is rated/received certificates of: UK:12
Marion Ravenwood. To learn about her, watch Raiders of the Lost Ark and Kingdom of the Crystal Skull.