There are about 991 miles between Orlando, FL and St. Louis, MO.
Take I-70 EAST to I-57 NORTH in Effingham. Continue on I-57 NORTH to CHICAGO.Take I-57 NORTH to Champaign-Urbana.
The shortest time is 28 hours..
The shortest driving distance is 817 miles.
992.5 driving miles.
About 15 hours 33 minutes.
It is 993,55 miles according to MapQuest.
Route 1: St. Lawrence Seaway (including Lake Champlain shortcut)
I-71 South to Columbus, then I-70 West through Indianapolis and on to St. Louis.
St. Louis, MO (STL) to Washington, DC (WAS) Shortest Flight Duration 2 hours 0 mins
300 miles taking this route:Take I-44 WEST, from St. Louis, to ROUTE 43 - SOUTH to SENECA at EXIT 4.Take ROUTE 43 - SOUTH to Seneca.
The shortest driving distance is 821 miles.