Chargaff's rule is adenine ALWAYS goes with thymine
guanine ALWAYS goes with cytosine
The rule that in DNA there is always equality in quantity between the bases A and T and between the bases G and C.
Chargaff
He didnt discover DNA, Erwin Chargaff proposed two main rules in his lifetime which were appropriately named Chargaff's rules. The first and best known achievement was to show that in natural DNA the number of guanine units equals the number of cytosine units and the number of adenine units equals the number of thymine units. The second of Chargaff's rules is that the composition of DNA varies from one species to another, in particular in the relative amounts of A, G, T, and C bases. Such evidence of molecular diversity, which had been presumed absent from DNA, made DNA a more credible candidate for the genetic material than protein.
Erwin Chargaff proposed two main rules in his lifetime which were appropriately named Chargaff's rules. The first and best known achievement was to show that in natural DNA the number of guanine units equals the number of cytosine units and the number of adenine units equals the number of thymine units. The second of Chargaff's rules is that the composition of DNA varies from one species to another, in particular in the relative amounts of A, G, T, and C bases. Such evidence of molecular diversity, which had been presumed absent from DNA, made DNA a more credible candidate for the genetic material than protein.
Chargaff's rule means that there should be the same number of purine and pyrimidine bases in DNA. The base pairing rules means that A always pairs with T, and G always pairs with C ie. a purine always pairs with a pyrimidine, so there must be the same number of both proving Chargaff's rule.
James Watson and Francis Crick are credited with the base pairing rules and DNA structure in general. Erwin Chargaff is credited with the rules of base pairs in that the number of pyrimidines is equal to the number of purines.
Erwin Chargaff
Chargaff
No, Erwin Chargaff did not win a Nobel Prize. He was an Austrian biochemist who is best known for his research on the composition of DNA, where he discovered the base pair rules known as Chargaff's rules.
How
cytosine
Chargaff's rules state that DNA from any cell of all organisms should have a 1:1 ratio of pyrimidine and purine bases and, more specifically, that the amount of guanine is equal to cytosine and the amount of adenine is equal to thymine.
Ernest Chargaff (Austrian) and Waclaw Szybalski (Polish).
In each species, the amount of adenine equals the amount of thymine.
adenine=thymine, cytosine=guanine
Chargaff's rule means that there should be the same number of purine and pyrimidine bases in DNA. The base pairing rules means that A always pairs with T, and G always pairs with C ie. a purine always pairs with a pyrimidine, so there must be the same number of both proving Chargaff's rule.
He didnt discover DNA, Erwin Chargaff proposed two main rules in his lifetime which were appropriately named Chargaff's rules. The first and best known achievement was to show that in natural DNA the number of guanine units equals the number of cytosine units and the number of adenine units equals the number of thymine units. The second of Chargaff's rules is that the composition of DNA varies from one species to another, in particular in the relative amounts of A, G, T, and C bases. Such evidence of molecular diversity, which had been presumed absent from DNA, made DNA a more credible candidate for the genetic material than protein.
Erwin Chargaff