HomeWhat a feedback inhibition of metabolic pathway is?
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when an enzyme that is active early in a metabolic pathway is inhibited by a product of the pathway.
an accumulation of effectors slows the pathway.
An enzyme near the beginning of a metabolic pathway is allosterically inhibited by the end product of the pathway. So the feedback inhibition realizes that once we get to a certin level of something made in the cell, it will become an allosteric enzyme and block production so nothing is overproduced in the cell.
One common example of feedback inhibition would be hexokinase being inhibited by its product glucose-6-phosphate in the glycolytic pathway. Mark S. 2008
Citrate synthase is inhibited by ATP. Obviously, the Krebs cycle produces ATP. This is the first step and one of the major regulatory steps in the pathway. If the cell has plenty of ATP, then it wouldn't need to keep making it, thus the pathway needs to be shut off. ATP inhibits the enzyme to shut off the pathway. This is an example of feedback inhibition (you can also call it negative inhibition or even product inhibition). Feedback inhibition is when the products of a certain biochemical pathway inhibit earlier enzymes, shutting down the pathway.
it is like "yo man, do what you're supposed to" and the biological pathway is like "oh, okay man, sorry"
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