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Adderall is basic (pH>7.0) and so becomes protonated (charged) at physiologic pH. Since charged particles are absorbed more slowly, this has two consequences: 1) the drug is absorbed more slowly when the intestine is acidic / faster when the intestine is basic. 2) the drug is RE-absorbed from the kidney lumen WORSE when the urine is acidic, so acidic urine tends to excrete more drug from the body.

Basically, avoid taking it with basic substances (baking soda, potassium citrate) or on an empty stomach - or the drug's concentrations may become elevated more rapidly, and last longer.

On a more observational note, some people show remarkably different "effects" while taking adderall, even at identical doses. ADHD individuals for example tend to be placated while others may BECOME hyperactive. The mechanism of is entirely unclear at this point.

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Adderall is absorbed immediately when it reaches the stomach. Capillary systems in the stomach lining absorb the amphetamine, which in turn travels through the circulatory system to the brain where it crosses the BBB and begins stimuating neurons. The remaining additives in the adderall are absorbed in the intestines and exit the body through urine. But that process can take an entire day so caffein wouldn't affect the rate of elimination of the drug. Caffeine is also a stimulant so it will just enhance the effects of Adderall. Base products such as magnesium and antacids can slow the rate of absorption of adderall making it last longer. However, it will not increase its potency.

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Q: What affects the effectiveness of Adderall?
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