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Depends on the type of drug and how much you are using it.

Alcohol is a depressant so it causes sluggish and fatigued behavior and when mixed with cocaine a known stimulant which causes manic behavior its telling your body to react in two contrasting ways slowing down and speeding up. If you have a high amount of both it gives mixed signals two your body as it is trying to defuse both toxins within your body but one way conflicts with the other making your body four times as hard to accommodate both toxins in the body. This can lead to overdose, heart failure, or heart attack.

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Q: What are some consequences of using alcohol and other drugs?
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