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Te most important advance towards our understanding of the cellular basis of antibody response was provided by the clone selection theory by Mac Farlane Burnet in 1957.
Clonal selection is responsible for the proliferation of clones of effector and memory cells specific for an encountered antigen
T cells
False
Lymph node
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Clonal selection and differentiation of lymphocytes provide the basis for immunological memory.
The Clonal Selection Theory explain how the immune system can be both diverse and very specific at the same time.The theory states:All antibodies are precommitted to making a single antibody with a single specificityA single cell produces only one antibody which interacts with only one antigen with the highest specificityWhen the right antigen interacts with that cell, it leads to clonal expansion and proliferation of that cell, so that many daughter-cells are made with the exact same specificityThe ability to recognise an antigen is dependent on a receptor, and the receptor is a product of the same cell that secretes the antibody. This ensures that made antibodies will fit with the antigen they are supposed to bind.A clone is defined as a group of cells in which all daughter cells are equal in their specificity
Natural Selection
1. An antigen presenting cell presents antigen on Class II MHC to a Helper T cell activating it 2. At the same time a B cell that has taken up and degraded the same pathogen displays antigen on its class II 3. The activated helper T cell binds to the B cell releasing cytokines and activating it 4. The activated B cell proliferates and differentiates into: 1) memory B cells 2) antibody-secreting plasma cells that produce antibodies specific for the pathogen
Darwin's theory of evolution.
Natural selection