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The Clonal Selection Theory explain how the immune system can be both diverse and very specific at the same time.The theory states:
- All antibodies are precommitted to making a single antibody with a single specificity
- A single cell produces only one antibody which interacts with only one antigen with the highest specificity
- When the right antigen interacts with that cell, it leads to clonal expansion and proliferation of that cell, so that many daughter-cells are made with the exact same specificity
- The ability to recognise an antigen is dependent on a receptor, and the receptor is a product of the same cell that secretes the antibody. This ensures that made antibodies will fit with the antigen they are supposed to bind.
A clone is defined as a group of cells in which all daughter cells are equal in their specificity
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What is clonal selection theory?
Te most important advance towards our understanding of the cellular basis of antibody response was provided by the clone selection theory by Mac Farlane Burnet in 1957.
What is clonal selection responsible for?
Clonal selection is responsible for the proliferation of clones of effector and memory cells specific for an encountered antigen
Antigen presentation is essential for the activation and clonal selection of?
T cells
According to the clonal selection theory foreign antigens select and interact with surface receptors only on the membranes of those specific lymphocytes that are genetically capable of making antibod?
False
What area is antigen challenge and clonal selection most likely to occur?
Lymph node
What nonlymphocyte cell is a central actor in clonal selection?
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What is the basis of immunological memory?
Clonal selection and differentiation of lymphocytes provide the basis for immunological memory.
What type of selection pushed Darwin's theory?
Natural Selection
What is the clonal selection theory as it applies to B cells?
1. An antigen presenting cell presents antigen on Class II MHC to a Helper T cell activating it 2. At the same time a B cell that has taken up and degraded the same pathogen displays antigen on its class II 3. The activated helper T cell binds to the B cell releasing cytokines and activating it 4. The activated B cell proliferates and differentiates into: 1) memory B cells 2) antibody-secreting plasma cells that produce antibodies specific for the pathogen
What theory does the natural selection belong to?
Darwin's theory of evolution.
What is drwin's theory?
Natural selection
What principles is not part of Darwin's original theory of evolution by natural selection?
Random processes are not part of the theory of evolution by natural selection.
