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What are the chemical content found in lansium domesticum seeds?

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10/04/2007

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An arrow poison has been made from the fruit peel and the bark of the tree. Both possess a toxic property, lansium acid, which, on injection, arrests heartbeat in frogs. The peel is reportedly high in tannin. The seed contains a minute amount of an unnamed alkaloid, 1% of an alcohol-soluble resin, and 2 bitter, toxic principles.

Phytochemistry. 2006 Oct;67(20):2288-93. Epub 2006 Aug 23.

Antimalarial tetranortriterpenoids from the seeds of Lansium domesticum Corr.

Saewan N, Sutherland JD, Chantrapromma K.

School of Science, Walailak University, Thasala, Nakhon Si Thammarat 80160,

Thailand. nisakorn@mfu.ac.th

Five tetranortriterpenoids, domesticulide A-E (1-5), were isolated from seeds of

Lansium domesticum Corr. together with 11 known triterpenoids (6-16). Their

structures were elucidated by analysis of their spectroscopic data. Compounds 2,

3, 4, 7, 8, 10, 11, and 15 showed antimalarial activity against Plasmodium

falciparum with IC(50)'s of 2.4-9.7 microg/ml.

PMID: 16930641 [PubMed - indexed for MEDLINE]