Acetaminophen (Tylenol)
Aleve (Naproxen)

What are the differences between ibuprofen acetaminophen naproxen and aspirin?

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2010-05-15 16:12:28

"NSAIDs_and_acetaminophen" id="NSAIDs_and_acetaminophen">NSAIDs and


Ibuprofen, naproxen and aspirin are all NSAIDs (non-steroidal anti

inflammatory drugs.) Among other actions their main mechanism of

action is to block a group of enzymes called COX (cyclo-oxygenase)

enzymes. They reduce pain (analgesic), reduce high temperatures

(antipyrexial), reduce swelling (anti-inflammatory) and make the

blood less likely to clot (antithrombolic). As they're all in the

same group, they all have similar side effects and risks, however

the severity of each side effect varies across the drugs, for

instance naproxen is less likely to cause heart problems than

ibuprofen. Common side effects include gastric irritation (the

reason they should be taken with food) and bleeding. Other drugs in

this group include diclofenac and the coxibs (however these have

more specific action).

Acetaminophen (paracetamol), is not an NSAID and acts via

different mechanisms. It shares the analgesic and antipyretic

properties of the NSAIDs, but in not anti-inflammatory or

antithrombolic. It is broken down in the body by the liver, unlike

NSAIDS which are removed via the kidneys, and have very different

side effects.

Acetaminophen can be taken with an NSAID, however you should not

take more than one NSAID at a time.

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