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- Production involves the use of mice. These mice are used to produce both antibodies and tumour cells. The production of tumour cells involves deliberately inducing cancer in mice. Despite specific guidelines drawn up to minimise any suffering, some people still have reservations about using animals in this way.
- To eliminate the need for humanisation of the antibody, transgenic mice can be used. In this case, a human gene is placed in the mice to that they can produce human antibodies rather than mouse antibodies. This raises the whole debate surrounding the ethics of genetic engineering.
- Monoclonal antibodies have been used successfully to treat a number of diseases, including cancer and Diabetes, saving many lives. There have also been some deaths associated with their use in the treatment of multiple sclerosis.
- Testing for the safety of new drugs presents certain dangers. In march 2006, six healthy volunteers took part in the trial of new monoclonal antibody (TGN1412) in London. Within minutes they suffered multiple organ failure, probably as a result of T cells overproducing chemicals that stimulate an immune response or attacking the body tissues. All the volunteers survived, but it raises issues about the conduct of drug trials.
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How do monoclonal antibodies help in controlling plant disease?
how do monoclonal antibodies help controlling plant disease?
What is monoclonal?
Monoclonal-- Genetically engineered antibodies specific for one antigen.
What did Cesar milstein discover?
monoclonal antibodies
What diseases are being treated with monoclonal antibodies?
Monoclonal antibodies are commonly used to fight a large number of diseases including cancer. The monoclonal antibodies fight the disease by targeting a certain antigen and recruiting the body's natural immune system to destroy the antigen-infected cells.
Are Monoclonal antibodies are not normally found in humans?
yes
What does the medical abbreviation MOABS mean?
Monoclonal Antibodies
What purpose does monoclonal antibodies serve?
To kill things
What is the recommended method for the production of monoclonal antibodies?
malkat singh
Monoclonal antibodies re used for diagnosis of juvenile diabetes?
No they can not
How are monoclonal antibodies used in home pregnancy kits?
During pregnancy a hormone called HCG (Human Chorionic Gonadotrophin is release,this hormone is detected by a special chemical called Monoclonal antibodies what this monoclonal antibodies does is attaches itself to the to the HCG hormone forming a colored band which indicates whether or not a woman is pregnant.
Monoclonal antibodies used as targeted drug delivery system?
yes
Construction and fermentation of Antibody drug?
Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are made by identical immune cells that are all clones of a unique parent cell, in contrast to polyclonal antibodies which are made from several different immune cells. Monoclonal antibodies have monovalent affinity, in that they bind to the same epitope. Given almost any substance, it is possible to produce monoclonal antibodies that specifically bind to that substance; they can then serve to detect or purify that substance. This has become an important tool in biochemistry, molecular biology and medicine. When used as medications, the non-proprietary drug name ends in -mab (see "Nomenclature of monoclonal antibodies"), and many immunotherapy specialists use the word mab anacronymically.
